Painkillers: A Comprehensive Guide to Their Uses and Benefits
pain management

Before discussing the treatment methods for pain, you must know a few things about pain. Pain is a natural response to any injury, tissue, or nerve damage in the body. Pain is a very disturbing and uncomfortable feeling. Every one of us experiences some kind of pain time and again. Pain can be short-term and goes away when you heal. But sometimes pain lasts longer than normal from days to months and months to years.

Reasons that may cause pain

  • any injury
  • disease or disorder
  • stress and anxiety
  • sometimes treatment of other medical conditions may also cause pain

Management of pain is very important to live a quality life. Because without management, it keeps on increasing and interferes with every action of yours. Prolonged pain affects your life in every possible way. Most people don’t take pain seriously and don’t do anything to manage that pain. With time that pain increases and takes a toll all over your body and mind. So, it is very important to manage pain to protect yourself from more pain and harm.

Pain management involves different methods and techniques and sometimes a combination of them. These methods help people with acute pain and severe pain as well. You know there are many ways to manage pain and one of them is medications. A wide range of medications are used in pain management like:

  • over-the-counter painkillers
  • prescription painkillers
  • corticosteroids
  • opioids
  • antidepressants
  • anticonvulsants

This article will help you know how prescription painkillers and opioids work for pain management. Along with that, you will also learn the benefits of these medicines. Here we will discuss about three painkillers – Tramadol, Pregabalin, and Tapentadol.

Working mechanism and benefits of Tramadol, Pregabalin, and Tapentadol

Tramadol, Tapentadol, and Pregabalin are very effective medicines for pain management. The working mechanism, dosage, and benefits of all these medicines are different from one another. You should consult with your doctor to choose the right medicine for you. Factors like your age, severity of pain, and underlying medical conditions play a major role in choosing the right medicine.


Tramadol is a very strong pain relief medication. It works great for moderate to severe pain and is used only when other painkillers don’t work. Tramadol is an opioid agonist and it has a dual working mechanism for pain relief. It binds to the opioid receptors and blocks the nerves that send pain signals from the affected body part to the brain. Due to this, you receive pain at a very low intensity. Along with that, it increases the levels of serotonin and norepinephrine in the brain. Increased levels of both these chemicals increase your pain tolerance. Moreover, these chemicals will inhibit the nerves from sending pain signals to the brain .

Tramadol is an oral tablet and it comes in two forms with different strengths:

Immediate-release tablets: These tablets are available as 50 mg and 100 mg. These are fast-acting tablets and start working within an hour. The effects of these tablets peak after 2-3 hours in your body and last up to 6 hours.

Extended-release tablets: These are slow-acting tablets and are available as 100 mg, 200 mg, and 300 mg. They take a little more time to kick into your system. The effects of these tablets last up to 24 hours.


Tapentadol is also an opioid medicine and is very helpful in managing moderate to severe pain. But it is mainly used for managing severe pain for which non-opioid medicines are not helpful. This medicine is different from tramadol because its extended-release form also treats diabetic nerve pain.

Although the exact working mechanism of Tapentadol is not clear yet. But some studies show that it also binds with opioid receptors in the brain. by doing so, it blocks the transmission of pain signals from the body to the brain. Moreover, it also affects the levels of norepinephrine which changes your perception of handling pain.

Tapentadol comes in tablet form as well as injectables. Injectables are taken either intravenously or intramuscularly. It is also available in both immediate-release and extended-release forms buy tapentadol online.

The available strengths of these forms are:

Immediate release: 50 mg, 75 mg, 100 mg

Extended-release: 50 mg, 100 mg, 150 mg, 200 mg, 250 mg


Pregabalin is also a painkiller which is very helpful in treating acute to severe pain. Pregabalin differs from Tramadol and Tapentadol because it treats nerve pain. People find pregabalin very effective for fibromyalgia or neuropathic pain. Moreover, pregabalin also has anticonvulsant properties. So, people use it for seizures and epilepsy as well.

The working mechanism of Pregabalin is different from both Tramadol and Tapentadol. It mimics the actions of GABA in the brain. Pregabalin also reduces nerve activity like GABA. Due to this, you will receive pain with very little intensity. You should know stress and anxiety also contribute to pain. But by reducing the nerve activity, pregabalin reduces the anxiety as well.

Pregabalin comes in the form of oral capsules and oral solution as well. Oral capsules are available in the strengths – 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300mg, etc. Whereas the liquid form comes in a single strength i.e. 20 mg/ml.

All these medicines are very strong and potent painkillers. They treat moderate to severe pain very effectively. Although all these medicines are prescription medicines. So, you can these medicines with a prescription. Because you may develop tolerance to these medicines if you use them for long. Due to this, you will need a higher dose of these medicines to get the best results. If you are suffering from pain, you can take these medicines. But you should take these medicines under the doctor’s supervision. This will prevent you from their harmful effects and addiction.


Pain is not something that you can ignore. Because if ignore it, it will become worse and make your life hell. So, it is very important to treat pain on time to live a pain-free and blissful life. You can buy these painkillers by visiting the pharmacies online and offline. Buy pregabalin online 300mg UK in UK. It is a trusted resource for all types of medicines. You will get all the branded medicines here and you will get the best results from them. Moreover, we will deliver your order within 3-5 working days in UK. So, buy these painkillers and take them as per the prescription to cope with any kind of pain.

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